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Published data shows Seroquel is effective in treating core symptoms of bipolar depression, including the reduction of suicidal thoughts. It is estimated that 25% to 50% of people with bipolar, a severe mood disorder, attempt suicide at least once in their life. Significant new data published this month show that Seroquel is approximately twice as effective as placebo at reducing suicidal thoughts in patients with bipolar depression as early as one week after treatment. Seroquel is not approved for bipolar depression and Seroquel is licensed for the treatment of manic episodes associated with bipolar disorder and for the treatment of schizophrenia.
The BOLDER eight week, multi-centered, randomised, double-blind placebo-controlled study is thought to be the first published large-scale, controlled study to assess the efficacy of any pharmacological treatment in patients with bipolar I and bipolar II depression.2 The study showed that Seroquel significantly improved core symptoms of depression and anxiety improving 9 out of 10 MADRS items compared to placebo, these include inability to feel, apparent sadness, pessimistic thoughts and suicidal thoughts. In addition, Seroquel enhances quality of sleep and quality of life significantly compared to placebo and was found to be well tolerated.
There are at present few adequate treatments regimen available for bipolar depression, so patients and their clinicians struggle with this disabling condition. Current UK guidelines suggest the use of antidepressants for bipolar depression, which seems the obvious solution, but this carries a risk of switching into a manic state and destabilization over time. The benefits from mood stabilizers in the short term are variable. The results of this research, thus, make an necessary contribution to finding an effective, fast-acting treatment with few troublesome side effects" commented Professor Tony Hale, head of the Division of Psychiatry at the University of Kent.
Bipolar patients spend a third of their lives depressed, and the vast majority of bipolar patients who commit suicide do so when they are depressed. This study shows lesser incidence in suicidal thoughts and other depressive symptoms, with both doses of Seroquel, within the first week of treatment. It is particularly impressive that 53% of patients taking Seroquel attained remission, the gold-standard for improvement, within the 8 weeks of the study. The treatment was very well tolerated by patients of the particular disorder, concluded Professor Hale.